HIST4H4 Back

histone cluster 4, H4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HIST4H4
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Community Annotation of HIST4H4 Add / Edit HIST4H4: Annotations

No community annotations yet for HIST4H4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HIST4H4 is highly significantly mutated in
(none)
HIST4H4 is significantly mutated in
(none)
HIST4H4 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HIST4H4