HIPK2 Back

homeodomain interacting protein kinase 2

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NCBI Description of HIPK2
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HIPK2 is highly significantly mutated in
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HIPK2 is significantly mutated in
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HIPK2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HIPK2