3-hydroxyisobutyrate dehydrogenase

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HIBADH

This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde.

Community Annotation of HIBADH Add / Edit HIBADH: Annotations

No community annotations yet for HIBADH.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HIBADH is highly significantly mutated in
HIBADH is significantly mutated in
HIBADH is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HIBADH