HIBADH Back

3-hydroxyisobutyrate dehydrogenase

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NCBI Description of HIBADH
This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde.

Community Annotation of HIBADH Add / Edit HIBADH: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HIBADH is highly significantly mutated in
(none)
HIBADH is significantly mutated in
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HIBADH is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HIBADH