HGS Back

hepatocyte growth factor-regulated tyrosine kinase substrate

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NCBI Description of HGS

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.

Community Annotation of HGS Add / Edit HGS: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HGS is highly significantly mutated in
HGS is significantly mutated in
HGS is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HGS