HGF activator

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NCBI Description of HGFAC

The protein encoded by this gene belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.

Community Annotation of HGFAC Add / Edit HGFAC: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HGFAC is highly significantly mutated in
HGFAC is significantly mutated in
HGFAC is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HGFAC