HEYL Back

hairy/enhancer-of-split related with YRPW motif-like

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HEYL
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

Community Annotation of HEYL Add / Edit HEYL: Annotations

No community annotations yet for HEYL.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HEYL is highly significantly mutated in
(none)
HEYL is significantly mutated in
(none)
HEYL is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HEYL