HEY1 Back

hairy/enhancer-of-split related with YRPW motif 1

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NCBI Description of HEY1
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.

Community Annotation of HEY1 Add / Edit HEY1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HEY1 is highly significantly mutated in
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HEY1 is significantly mutated in
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HEY1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HEY1