HES7 Back

hairy and enhancer of split 7 (Drosophila)

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NCBI Description of HES7
This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HES7 is highly significantly mutated in
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HES7 is significantly mutated in
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HES7 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HES7