HES5 Back

hairy and enhancer of split 5 (Drosophila)

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NCBI Description of HES5
This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HES5 is highly significantly mutated in
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HES5 is significantly mutated in
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HES5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HES5