HES1 Back

hairy and enhancer of split 1, (Drosophila)

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NCBI Description of HES1

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.

Community Annotation of HES1 Add / Edit HES1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HES1 is highly significantly mutated in
HES1 is significantly mutated in
HES1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HES1