HERC3 Back

hect domain and RLD 3

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NCBI Description of HERC3

This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of HERC3 Add / Edit HERC3: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HERC3 is highly significantly mutated in
HERC3 is significantly mutated in
HERC3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HERC3