HEPN1 Back

hepatocellular carcinoma, down-regulated 1

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NCBI Description of HEPN1
This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). Also to note is that this gene maps to the 3'-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand (PMID:15885354).

Community Annotation of HEPN1 Add / Edit HEPN1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HEPN1 is highly significantly mutated in
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HEPN1 is significantly mutated in
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HEPN1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HEPN1