HDAC9 Back

histone deacetylase 9

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HDAC9
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.

Community Annotation of HDAC9 Add / Edit HDAC9: Annotations

No community annotations yet for HDAC9.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HDAC9 is highly significantly mutated in
(none)
HDAC9 is significantly mutated in
(none)
HDAC9 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HDAC9