HDAC8 Back

histone deacetylase 8

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NCBI Description of HDAC8
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of HDAC8 Add / Edit HDAC8: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HDAC8 is highly significantly mutated in
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HDAC8 is significantly mutated in
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HDAC8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HDAC8