HDAC7 Back

histone deacetylase 7

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NCBI Description of HDAC7

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of HDAC7 Add / Edit HDAC7: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HDAC7 is highly significantly mutated in
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HDAC7 is significantly mutated in
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HDAC7 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for HDAC7