HDAC4 Back

histone deacetylase 4

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NCBI Description of HDAC4
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Community Annotation of HDAC4 Add / Edit HDAC4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HDAC4 is highly significantly mutated in
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HDAC4 is significantly mutated in
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HDAC4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HDAC4