HDAC2 Back

histone deacetylase 2

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NCBI Description of HDAC2
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.

Community Annotation of HDAC2 Add / Edit HDAC2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HDAC2 is highly significantly mutated in
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HDAC2 is significantly mutated in
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HDAC2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HDAC2