HCN1 Back

hyperpolarization activated cyclic nucleotide-gated potassium channel 1

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NCBI Description of HCN1
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of HCN1 Add / Edit HCN1: Annotations

No community annotations yet for HCN1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HCN1 is highly significantly mutated in
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HCN1 is significantly mutated in
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HCN1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HCN1