HCFC2 Back

host cell factor C2

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NCBI Description of HCFC2

This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described.

Community Annotation of HCFC2 Add / Edit HCFC2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HCFC2 is highly significantly mutated in
HCFC2 is significantly mutated in
HCFC2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HCFC2