holocytochrome c synthase (cytochrome c heme-lyase)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HCCS

The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene.

Community Annotation of HCCS Add / Edit HCCS: Annotations

No community annotations yet for HCCS.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HCCS is highly significantly mutated in
HCCS is significantly mutated in
HCCS is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HCCS