GZMM Back

granzyme M (lymphocyte met-ase 1)

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NCBI Description of GZMM
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of GZMM Add / Edit GZMM: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GZMM is highly significantly mutated in
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GZMM is significantly mutated in
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GZMM is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GZMM