GZMB Back

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

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NCBI Description of GZMB
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Community Annotation of GZMB Add / Edit GZMB: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GZMB is highly significantly mutated in
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GZMB is significantly mutated in
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GZMB is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GZMB