GUCY2F Back

guanylate cyclase 2F, retinal

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NCBI Description of GUCY2F
The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no transcript sequence was available to make the entire refseq consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments.

Community Annotation of GUCY2F Add / Edit GUCY2F: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GUCY2F is highly significantly mutated in
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GUCY2F is significantly mutated in
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GUCY2F is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GUCY2F