GUCY1A3 Back

guanylate cyclase 1, soluble, alpha 3

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NCBI Description of GUCY1A3

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene.

Community Annotation of GUCY1A3 Add / Edit GUCY1A3: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GUCY1A3 is highly significantly mutated in
GUCY1A3 is significantly mutated in
GUCY1A3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GUCY1A3