GUCY1A2 Back

guanylate cyclase 1, soluble, alpha 2

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NCBI Description of GUCY1A2

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of GUCY1A2 Add / Edit GUCY1A2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GUCY1A2 is highly significantly mutated in
GUCY1A2 is significantly mutated in
GUCY1A2 is near significance in

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Data details

Mutation list for GUCY1A2