GUCA2B Back

guanylate cyclase activator 2B (uroguanylin)

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NCBI Description of GUCA2B
This gene encodes a member of the guanylin family, and is expressed in the stomach and intestine. This protein functions as an endogenous ligand for the guanylate cyclase-C receptor and stimulates an increase in cyclic GMP, a key component of several intracellular signal transduction pathways. It maybe involved in salt and water secretion into the intestinal lumen as well as the renal tubules, and thus regulate electrolyte homeostasis in these tissues.

Community Annotation of GUCA2B Add / Edit GUCA2B: Annotations

No community annotations yet for GUCA2B.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GUCA2B is highly significantly mutated in
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GUCA2B is significantly mutated in
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GUCA2B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GUCA2B