GTF3C6 Back

general transcription factor IIIC, polypeptide 6, alpha 35kDa

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NCBI Description of GTF3C6

RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.[supplied by OMIM, Mar 2008].

Community Annotation of GTF3C6 Add / Edit GTF3C6: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GTF3C6 is highly significantly mutated in
GTF3C6 is significantly mutated in
GTF3C6 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GTF3C6