GTF2H3 Back

general transcription factor IIH, polypeptide 3, 34kDa

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NCBI Description of GTF2H3

This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14.

Community Annotation of GTF2H3 Add / Edit GTF2H3: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GTF2H3 is highly significantly mutated in
GTF2H3 is significantly mutated in
GTF2H3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GTF2H3