GSTZ1 Back

glutathione transferase zeta 1 (maleylacetoacetate isomerase)

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NCBI Description of GSTZ1

This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GSTZ1 is highly significantly mutated in
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GSTZ1 is significantly mutated in
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GSTZ1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for GSTZ1