GSR Back

glutathione reductase

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of GSR

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.

Community Annotation of GSR Add / Edit GSR: Annotations

No community annotations yet for GSR.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GSR is highly significantly mutated in
(none)
GSR is significantly mutated in
(none)
GSR is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for GSR