GSN Back

gelsolin (amyloidosis, Finnish type)

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NCBI Description of GSN
The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.

Community Annotation of GSN Add / Edit GSN: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GSN is highly significantly mutated in
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GSN is significantly mutated in
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GSN is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GSN