GRK4 Back

G protein-coupled receptor kinase 4

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NCBI Description of GRK4

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.

Community Annotation of GRK4 Add / Edit GRK4: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GRK4 is highly significantly mutated in
GRK4 is significantly mutated in
GRK4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GRK4