GRK1 Back

G protein-coupled receptor kinase 1

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NCBI Description of GRK1
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2).

Community Annotation of GRK1 Add / Edit GRK1: Annotations

No community annotations yet for GRK1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GRK1 is highly significantly mutated in
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GRK1 is significantly mutated in
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GRK1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GRK1