GRIN3A Back

glutamate receptor, ionotropic, N-methyl-D-aspartate 3A

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NCBI Description of GRIN3A
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GRIN3A is highly significantly mutated in
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GRIN3A is significantly mutated in
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GRIN3A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GRIN3A