GRIK1 Back

glutamate receptor, ionotropic, kainate 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of GRIK1
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.

Community Annotation of GRIK1 Add / Edit GRIK1: Annotations

No community annotations yet for GRIK1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GRIK1 is highly significantly mutated in
(none)
GRIK1 is significantly mutated in
(none)
GRIK1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GRIK1