GRB7 Back

growth factor receptor-bound protein 7

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NCBI Description of GRB7
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene.

Community Annotation of GRB7 Add / Edit GRB7: Annotations

No community annotations yet for GRB7.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GRB7 is highly significantly mutated in
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GRB7 is significantly mutated in
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GRB7 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GRB7