NCBI Description of GRB2
|The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.|
Community Annotation of GRB2 Add / Edit GRB2: Annotations
No community annotations yet for GRB2.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.