GRB2 Back

growth factor receptor-bound protein 2

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NCBI Description of GRB2
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of GRB2 Add / Edit GRB2: Annotations

No community annotations yet for GRB2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GRB2 is highly significantly mutated in
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GRB2 is significantly mutated in
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GRB2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GRB2