GRAP2 Back

GRB2-related adaptor protein 2

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NCBI Description of GRAP2
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.

Community Annotation of GRAP2 Add / Edit GRAP2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GRAP2 is highly significantly mutated in
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GRAP2 is significantly mutated in
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GRAP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GRAP2