GPX2 Back

glutathione peroxidase 2 (gastrointestinal)

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NCBI Description of GPX2
This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described.

Community Annotation of GPX2 Add / Edit GPX2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GPX2 is highly significantly mutated in
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GPX2 is significantly mutated in
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GPX2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GPX2