GPSM1 Back

G-protein signaling modulator 1 (AGS3-like, C. elegans)

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NCBI Description of GPSM1

G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GPSM1 is highly significantly mutated in
GPSM1 is significantly mutated in
GPSM1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GPSM1