GPRASP1 Back

G protein-coupled receptor associated sorting protein 1

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NCBI Description of GPRASP1
This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified.

Community Annotation of GPRASP1 Add / Edit GPRASP1: Annotations

No community annotations yet for GPRASP1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GPRASP1 is highly significantly mutated in
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GPRASP1 is significantly mutated in
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GPRASP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GPRASP1