GPNMB Back

glycoprotein (transmembrane) nmb

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NCBI Description of GPNMB
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of GPNMB Add / Edit GPNMB: Annotations

No community annotations yet for GPNMB.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GPNMB is highly significantly mutated in
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GPNMB is significantly mutated in
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GPNMB is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GPNMB