glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

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NCBI Description of GPIHBP1

Dietary fats are packaged by intestine into triglyceride-rich lipoproteins called chylomicrons. The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LPL: MIM 609708) along the luminal surface of capillaries, mainly in heart, skeletal muscle, and adipose tissue. GPIHBP1 is a capillary endothelial cell protein that provides a platform for LPL-mediated processing of chylomicrons (Beigneux et al., 2007 [PubMed 17403372]).[supplied by OMIM, Apr 2009].

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GPIHBP1 is highly significantly mutated in
GPIHBP1 is significantly mutated in
GPIHBP1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GPIHBP1