GPD2 Back

glycerol-3-phosphate dehydrogenase 2 (mitochondrial)

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NCBI Description of GPD2

The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.

Community Annotation of GPD2 Add / Edit GPD2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GPD2 is highly significantly mutated in
GPD2 is significantly mutated in
GPD2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GPD2