GPBP1 Back

GC-rich promoter binding protein 1

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NCBI Description of GPBP1

This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Community Annotation of GPBP1 Add / Edit GPBP1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GPBP1 is highly significantly mutated in
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GPBP1 is significantly mutated in
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GPBP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for GPBP1