GOT1 Back

glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)

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NCBI Description of GOT1

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.

Community Annotation of GOT1 Add / Edit GOT1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GOT1 is highly significantly mutated in
GOT1 is significantly mutated in
5 patients (2%)
GOT1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GOT1