GNRH1 Back

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

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NCBI Description of GNRH1
The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GNRH1 is highly significantly mutated in
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GNRH1 is significantly mutated in
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GNRH1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GNRH1