GNPDA2 Back

glucosamine-6-phosphate deaminase 2

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NCBI Description of GNPDA2

The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Community Annotation of GNPDA2 Add / Edit GNPDA2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GNPDA2 is highly significantly mutated in
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GNPDA2 is significantly mutated in
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GNPDA2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for GNPDA2