GNAQ Back

guanine nucleotide binding protein (G protein), q polypeptide

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NCBI Description of GNAQ
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.

Community Annotation of GNAQ Add / Edit GNAQ: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GNAQ is highly significantly mutated in
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GNAQ is significantly mutated in
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GNAQ is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GNAQ