GNAI3 Back

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3

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NCBI Description of GNAI3

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GNAI3 is highly significantly mutated in
GNAI3 is significantly mutated in
GNAI3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GNAI3